Santos R B, Lemos C, Saraiva M (March 21, 2023) Gender-Affirming Hormone Therapy: Physical and Sociopsychological Effects, Impact and Satisfaction. Cureus 15(3): e36484. doi:10.7759/cureus.36484
Though the article indicates that satisfaction with gender-affirming hormone therapy was high (4.5 on a 0-6 scale), the side effects were significant:
| SEa of masculinizing GAHT | Group M (n=87) | SEa of feminizing GAHT | Group F (n=27) |
| Mood swings | 56.3 | Decreased libido | 66.7 |
| Acne | 52.9 | Mood swings | 63.0 |
| Alopecia | 37.9 | Exanthema | 14.8 |
| Pelvic/clitoral pain | 23.0 | Nausea/vomiting | 14.8 |
| Erythrocytosis | 10.3 | Dyslipidemia | 7.4 |
| Dyslipidemia | 8.0 | Hypertension | 7.4 |
| Hypertension | 4.6 | Venous thromboembolism | 7.4 |
| Exanthema | 2.3 | Stroke | 3.7 |
| Hepatic toxicity | 2.3 | Acute myocardial infarction | 3.7 |
| Hyperprolactinemia | 3.7 |