Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AngioImmunoblastic T cell Lymphoma (AITL)
“This observation, which has been posted as a pre-print on the SSRN platform (18 (https://www.frontiersin.org/articles/10.3389/fmed.2021.798095/full#B18)), suggests that vaccination with the BNT162b2 mRNA vaccine might induce rapid progression of AITL. Dedicated studies are needed to determine whether this case can be extrapolated to populations of patients with AITL or other peripheral T cell lymphoma involving TFH cells.”
https://www.frontiersin.org/articles/10.3389/fmed.2021.798095/full
