“Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform.
The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of pre-exposure to the mRNA-LNP on adaptive immune (https://en.wikipedia.org/wiki/Adaptive_immune_system)responses and innate immune (https://en.wikipedia.org/wiki/Innate_immune_system)fitness. We found that pre-exposure to mRNA-LNPs or LNP alone led to long-term inhibition of the adaptive immune responses …
In summary, the mRNA-LNP vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections”
https://www.biorxiv.org/content/10.1101/2022.03.16.484616v2) / PDF (https://www.biorxiv.org/content/10.1101/2022.03.16.484616v2.full.pdf