Pre-Exposure to mRNA-LNP Inhibits Adaptive Immune Responses and Alters Innate Immune Fitness in an Inheritable Fashion

“Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform.

The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of pre-exposure to the mRNA-LNP on adaptive immune (https://en.wikipedia.org/wiki/Adaptive_immune_system)responses and innate immune (https://en.wikipedia.org/wiki/Innate_immune_system)fitness. We found that pre-exposure to mRNA-LNPs or LNP alone led to long-term inhibition of the adaptive immune responses …

In summary, the mRNA-LNP vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections”

https://www.biorxiv.org/content/10.1101/2022.03.16.484616v2) / PDF (https://www.biorxiv.org/content/10.1101/2022.03.16.484616v2.full.pdf

Published by markskidmore

Mark Skidmore is Professor of Economics at Michigan State University where he holds the Morris Chair in State and Local Government Finance and Policy. His research focuses on topics in public finance, regional economics, and the economics of natural disasters. Mark created the Lighthouse Economics website and blog to share economic research and information relevant for navigating tumultuous times.

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